H2N2V1, Main, Exploration, bibRecord, 001900

Recognition of N-glycolylneuraminic acid linked to galactose by the alpha2,3 linkage is associated with intestinal replication of influenza A virus in ducks.

Identifieur interne : 001900 ( Main/Exploration ); précédent : 001899; suivant : 001901

Recognition of N-glycolylneuraminic acid linked to galactose by the alpha2,3 linkage is associated with intestinal replication of influenza A virus in ducks.

Auteurs : T. Ito [États-Unis] ; Y. Suzuki ; T. Suzuki ; A. Takada ; T. Horimoto ; K. Wells ; H. Kida ; K. Otsuki ; M. Kiso ; H. Ishida ; Yoshihiro Kawaoka [États-Unis]

Source :

Journal of virology [ 0022-538X ] ; 2000.

RBID : pubmed:10982377

Descripteurs français

KwdFr :
- Acides neuraminiques, Animaux, Canards (virologie), Galactose, Grippe humaine (virologie), Humains, Hémagglutinines virales (physiologie), Réplication virale, Virus de la grippe A (physiologie).
MESH :
- physiologie : Hémagglutinines virales, Virus de la grippe A.
- virologie : Canards, Grippe humaine.
- Acides neuraminiques, Animaux, Galactose, Humains, Réplication virale.

English descriptors

KwdEn :
- Animals, Ducks (virology), Galactose, Hemagglutinins, Viral (physiology), Humans, Influenza A virus (physiology), Influenza, Human (virology), Neuraminic Acids, Virus Replication.
MESH :
- chemical , physiology : Hemagglutinins, Viral.
- chemical : Galactose, Neuraminic Acids.
- physiology : Influenza A virus.
- virology : Ducks, Influenza, Human.
- Animals, Humans, Virus Replication.

Abstract

The hemagglutinin (HA) of H3 human influenza viruses does not support viral replication in duck intestine despite its avian origin. A Leu-to-Gln mutation at position 226 and a Ser-to-Gly mutation at position 228 in the HA of human A/Udorn/307/72 (H3N2) permit a reassortant virus [human Udorn HA, with all other genes from A/mallard/New York/6750/78 (H2N2)] to replicate in ducks. To understand the molecular basis of this change in host range restriction, we investigated the receptor specificity of duck influenza viruses as well as of human-duck virus reassortants. The results indicate that the recognition of a glycoconjugate moiety possessing N-glycolneuramic acid (NeuGc) linked to galactose by the alpha2,3 linkage (NeuGcalpha2,3Gal) is associated with viral replication in duck intestine. Immunofluorescence assays with NeuGcalpha2,3Gal-specific antiserum detected this moiety primarily on the crypt epithelial cells of duck colon. Such recognition, together with biochemical evidence of NeuGc in crypt cells, correlated exactly with the ability of the virus to replicate in duck colon. These results suggest that recognition of the NeuGcalpha2,3-Gal moiety plays an important role in the enterotropism of avian influenza viruses.

DOI: 10.1128/jvi.74.19.9300-9305.2000
PubMed: 10982377

Affiliations:

Le document en format XML

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<term>Influenza, Human (virology)</term>
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<front><div type="abstract" xml:lang="en">The hemagglutinin (HA) of H3 human influenza viruses does not support viral replication in duck intestine despite its avian origin. A Leu-to-Gln mutation at position 226 and a Ser-to-Gly mutation at position 228 in the HA of human A/Udorn/307/72 (H3N2) permit a reassortant virus [human Udorn HA, with all other genes from A/mallard/New York/6750/78 (H2N2)] to replicate in ducks. To understand the molecular basis of this change in host range restriction, we investigated the receptor specificity of duck influenza viruses as well as of human-duck virus reassortants. The results indicate that the recognition of a glycoconjugate moiety possessing N-glycolneuramic acid (NeuGc) linked to galactose by the alpha2,3 linkage (NeuGcalpha2,3Gal) is associated with viral replication in duck intestine. Immunofluorescence assays with NeuGcalpha2,3Gal-specific antiserum detected this moiety primarily on the crypt epithelial cells of duck colon. Such recognition, together with biochemical evidence of NeuGc in crypt cells, correlated exactly with the ability of the virus to replicate in duck colon. These results suggest that recognition of the NeuGcalpha2,3-Gal moiety plays an important role in the enterotropism of avian influenza viruses.</div>
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Recognition of N-glycolylneuraminic acid linked to galactose by the alpha2,3 linkage is associated with intestinal replication of influenza A virus in ducks.

Recognition of N-glycolylneuraminic acid linked to galactose by the alpha2,3 linkage is associated with intestinal replication of influenza A virus in ducks.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

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Pour mettre un lien sur cette page dans le réseau Wicri

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